Insights Into Causal Pathways for Ischemic Heart Disease

Background— The purpose of this study was to assess the relation of adverse childhood experiences (ACEs), including abuse, neglect, and household dysfunction, to the risk of ischemic heart disease (IHD) and to examine the mediating impact on this relation of both traditional IHD risk factors and psychological factors that are associated with ACEs. Methods and Results— Retrospective cohort survey data were collected from 17 337 adult health plan...