TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
Abstract
TopHat is a popular spliced aligner for RNA-sequence (RNA-seq) experiments. In this paper, we describe TopHat2, which incorporates many significant enhancements to TopHat. TopHat2 can align reads of various lengths produced by the latest sequencing technologies, while allowing for variable-length indels with respect to the reference genome. In addition to de novo spliced alignment, TopHat2 can align reads across fusion breaks, which can occur...
Paper Details
Title
TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
Published Date
Jan 1, 2013
Volume
14
Issue
4
Pages
R36 - R36
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