Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals? An examination of the set-point theory

Obese persons generally regain lost weight, suggesting that adaptive metabolic changes favor return to a preset weight.Our objective was to determine whether adaptive changes in resting metabolic rate (RMR) and thyroid hormones occur in weight-reduced persons, predisposing them to long-term weight gain.Twenty-four overweight, postmenopausal women were studied at a clinical research center in four 10-d study phases: the overweight state (phase 1,...