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Using best-worst scaling in horizon scanning for hepatocellular carcinoma technologies

Published on Jul 1, 2012in International Journal of Technology Assessment in Health Care1.42
· DOI :10.1017/S026646231200027X
Gisselle Gallego6
Estimated H-index: 6
(Johns Hopkins University),
John F. P. Bridges27
Estimated H-index: 27
(Johns Hopkins University)
+ 2 AuthorsLouis Niessen29
Estimated H-index: 29
(Johns Hopkins University)
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Abstract
There is a growing need for efficient procedures for identification of emerging technologies by horizon scanning systems. We demonstrate the value of best-worst scaling (BWS) in exploring clinicians' views on emerging technologies that will impact outcomes in hepatocellular carcinoma (HCC) in the next 5 to 10 years.
  • References (22)
  • Citations (17)
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References22
Newest
Published on Dec 1, 2011in Health Research Policy and Systems2.22
John F. P. Bridges27
Estimated H-index: 27
(Johns Hopkins University),
Gisselle Gallego6
Estimated H-index: 6
(Johns Hopkins University),
Barri M. Blauvelt7
Estimated H-index: 7
(UMass: University of Massachusetts Amherst)
Background Liver cancer is the fifth most common cancer in men and the seventh for women. Usually because of late diagnosis, the prognosis for liver cancer remains poor, resulting in liver cancer being the third most common cause of death from cancer. While some countries have treatment guidelines, little is known or understood about the strategies needed for liver cancer control internationally.
Published on Jun 1, 2011in Journal of Hepatology18.95
Joseph Torresi39
Estimated H-index: 39
(University of Melbourne),
Douglas F. Johnson14
Estimated H-index: 14
(University of Melbourne),
Heiner Wedemeyer70
Estimated H-index: 70
Hepatitis C virus (HCV) is a blood borne disease estimated to chronically infect 3% of the worlds' population causing significant morbidity and mortality. Current medical therapy is curative in approximately 50% of patients. While recent treatment advances of genotype 1 infection using directly acting antiviral agents (DAAs) are encouraging, there is still a need to develop vaccine strategies capable of preventing infection. Moreover, vaccines may also be used in future in combination with DAAs ...
Published on Jan 16, 2011in International Journal of Clinical Practice2.61
Rosemary Lord2
Estimated H-index: 2
,
Abid Suddle9
Estimated H-index: 9
(University of Cambridge),
Paul Ross22
Estimated H-index: 22
(University of Cambridge)
Summary Hepatocellular cancer (HCC) is the fifth most common cause of cancer worldwide and its incidence is increasing as a result of the dissemination of hepatitis B and C virus infection. Surgical resection and liver transplantation are considered the only cures for HCC, but benefit approximately 10–15% of patients. In addition, radiofrequency ablation may is potentially curative for patients’ with small HCC. Some patients with unresectable disease confined to the liver may benefit from emboli...
Published on Dec 1, 2010in Pharmacogenomics2.27
Boris Freidlin35
Estimated H-index: 35
(NIH: National Institutes of Health),
Edward L. Korn51
Estimated H-index: 51
Advancements made in molecularly targeted therapeutics have focussed increasing attention on biomarker-adaptive clinical trial designs as a means of improving the efficiency of drug development and advancing medical care. Here, we focus on randomized clinical trial (RCT) designs aimed at developing/validating clinically relevant pharmacogenomic biomarkers capable of identifying patients sensitive to a given therapy(s), and thereby, selecting the best therapy for a given patient. The term ‘biomar...
Jordan J. Louviere78
Estimated H-index: 78
(UTS: University of Technology, Sydney),
Terry N. Flynn31
Estimated H-index: 31
(UTS: University of Technology, Sydney)
Background: One of the greatest difficulties in evaluating healthcare system reform in any country is that governments often do not clearly articulate what it is they are attempting to do. In Australia, a recent inquiry set out 15 principles to guide the reform process, but it remains unclear how the Australian public values the principles, how such values vary across the country, and, more fundamentally, if Australians understand the principles.
Published on Nov 1, 2010in Oncologist5.25
Sheng Long Ye10
Estimated H-index: 10
(Fudan University),
Tadatoshi Takayama67
Estimated H-index: 67
+ 2 AuthorsJean Pierre Bronowicki22
Estimated H-index: 22
For patients with early-stage hepatocellular carcinoma (HCC), potentially curative treatment options exist, including liver transplantation, surgical resection, and ablation therapy. These treatments are associated with survival benefits, and outcomes are optimized by identification of appropriate patients. However, further studies are needed to definitively confirm optimal treatment approaches for all patients. Treatment patterns vary in different parts of the world as a result of geographic di...
Published on Apr 1, 2010in Canadian Journal of Surgery2.31
Tania Stafinski20
Estimated H-index: 20
,
Leigh-Ann Topfer6
Estimated H-index: 6
+ 1 AuthorsDevidas Menon27
Estimated H-index: 27
Contexte: L'evaluation des technologies de la sante (ETS) est un outil qui doit aider les responsables des politiques a choisir les technologies a financer. Toutefois, etant donne la proliferation de technologies nouvelles, il est impossible de soumettre chacune d'entre elles a une ETS avant qu'elle soit financee. C'est pourquoi on a etabli des processus d'« analyse prospective » pour determiner les technologies emergentes susceptibles d'avoir un effet important sur la pratique clinique. Meme si...
Published on Feb 1, 2010in Expert Opinion on Investigational Drugs4.03
Piotr J. Wysocki14
Estimated H-index: 14
Importance of the field: Hepatocellular cancer (HCC) is the fifth most common malignancy worldwide and third leading cause of cancer death. HCC is highly resistant to conventional systemic therapies, and prognosis for advanced HCC patients remains poor. However, identification of signaling pathways responsible for HCC growth and progression such as RAS/RAF/MEK/ERK or PI3K/AKT/mTOR has determined crucial molecular targets and led to development of novel promising targeted therapies.Areas covered ...
Published on Oct 1, 2009in Expert Review of Proteomics2.96
Xin-Qing Peng1
Estimated H-index: 1
,
Fei Wang3
Estimated H-index: 3
(Tianjin Medical University)
+ 1 AuthorsWei-Ming Zhang1
Estimated H-index: 1
(Tianjin Medical University)
Tumor proteomics apply proteomics techniques to tumor biological research, mainly by screening candidate biomarkers for early tumor diagnosis, prognosis and treatment. Hepatocellular carcinoma (HCC) is a type of malignant tumor with one of the highest death rates in the world. With the advent of the post-genomic age, tumor biological research developing the technology of proteomics has become a major focus of researchers. The discovery of novel candidate biomarkers is one of crucial problems for...
Cited By17
Newest
Published on Jul 1, 2019in Epilepsy & Behavior2.38
Sarah A. Janse (OSU: Ohio State University), Sonya B. Dumanis1
Estimated H-index: 1
(Epilepsy Foundation)
+ 3 AuthorsJohn Bridges2
Estimated H-index: 2
(OSU: Ohio State University)
Abstract Background Epilepsy is the 4th most common neurological disorder and is characterized by recurrent, unpredictable seizures. The ability to forecast seizures is a significant unmet need and would have a transformative effect on the lives of people living with epilepsy. In an effort to address this need, the Epilepsy Foundation has committed effort and resources to promote the development of seizure forecasting devices (SFD). Objective To promote user-centered design of future SFD, we sou...
Published on Nov 27, 2018in Journal of Medical Economics
Kei Long Cheung5
Estimated H-index: 5
(Medical University of Vienna),
Susanne Mayer6
Estimated H-index: 6
(Medical University of Vienna)
+ 4 AuthorsMickaël Hiligsmann27
Estimated H-index: 27
(PHRI: Public Health Research Institute)
AbstractAims: Different methods have been used to analyze “object case” best–worst scaling (BWS). This study aims to compare the most common statistical analysis methods for object case BWS (i.e. the count analysis, multinomial logit, mixed logit, latent class analysis, and hierarchical Bayes estimation) and to analyze their potential advantages and limitations based on an applied example.Methods: Data were analyzed using the five analysis methods. Ranking results were compared among the methods...
Published on May 1, 2019in Clinical Therapeutics2.94
Rosangel Cruz4
Estimated H-index: 4
,
Lisa Belter + 2 AuthorsJill Jarecki7
Estimated H-index: 7
Abstract Purpose Patients’ perceptions of benefit–risk are essential to informing the regulatory process and the context in which potential therapies are evaluated. To bring this critical information to regulators, Cure SMA launched a first-ever Benefit-Risk Survey for spinal muscular atrophy (SMA) to characterize decision-making and benefit–risk trade-offs in SMA associated with a potential therapy. We hypothesized that risk tolerance would be correlated with SMA type/severity and disease progr...
Published on Dec 1, 2018in Health Expectations2.85
Melissa C.W. Vaanholt1
Estimated H-index: 1
(UT: University of Twente),
Marlies M. Kok8
Estimated H-index: 8
(Medisch Spectrum Twente)
+ 2 AuthorsJanine Astrid van Til14
Estimated H-index: 14
(UT: University of Twente)
Objectives: To examine patients’ perspectives regarding composite endpoints and the utility patients put on possible adverse outcomes of revascularization procedures. Design: In the PRECORE study, a stated preference elicitation method Best-Worst Scaling (BWS) was used to determine patient preference for 8 component endpoints (CEs): need for redo percutaneous coronary intervention (PCI) within 1 year, minor stroke with symptoms <24 hours, minor myocardial infarction (MI) with symptoms <3 months,...
Published on May 1, 2017in Muscle & Nerve2.39
Ilene L. Hollin9
Estimated H-index: 9
(Johns Hopkins University),
Holly Peay14
Estimated H-index: 14
(RTP: Research Triangle Park)
+ 1 AuthorsJohn F. P. Bridges27
Estimated H-index: 27
(Johns Hopkins University)
Objective This study quantifies caregiver and patient preferences for a therapeutic agent with demonstrated pulmonary benefits for Duchenne muscular dystrophy (DMD). Caregivers and patient differences are also explored. Methods A best-worst scaling survey (BWS) was administered to caregivers and patients. Across 9 profiles, respondents selected the best and worst attributes. Utility scores were estimated using mixed logistic regression. Results Respondents indicated greatest preference for thera...
Published on Dec 1, 2016in Health Economics Review
Axel C. Mühlbacher16
Estimated H-index: 16
,
Anika Kaczynski5
Estimated H-index: 5
+ 1 AuthorsF. Reed Johnson35
Estimated H-index: 35
(Duke University)
Best-worst scaling (BWS), also known as maximum-difference scaling, is a multiattribute approach to measuring preferences. BWS aims at the analysis of preferences regarding a set of attributes, their levels or alternatives. It is a stated-preference method based on the assumption that respondents are capable of making judgments regarding the best and the worst (or the most and least important, respectively) out of three or more elements of a choice-set. As is true of discrete choice experiments ...
Published on Dec 1, 2016in PharmacoEconomics3.71
Kei Long Cheung5
Estimated H-index: 5
(UM: Maastricht University),
Ben F. M. Wijnen6
Estimated H-index: 6
(UM: Maastricht University)
+ 4 AuthorsMickaël Hiligsmann27
Estimated H-index: 27
(UM: Maastricht University)
Introduction Best–worst scaling (BWS) is becoming increasingly popular to elicit preferences in health care. However, little is known about current practice and trends in the use of BWS in health care. This study aimed to identify, review and critically appraise BWS in health care, and to identify trends over time in key aspects of BWS.
Published on Jul 1, 2016in Annals of Family Medicine4.18
Eve Wittenberg21
Estimated H-index: 21
(Harvard University),
Monica Bharel11
Estimated H-index: 11
(Harvard University)
+ 2 AuthorsLinda Weinreb20
Estimated H-index: 20
(UMMS: University of Massachusetts Medical School)
PURPOSE Best-worst scaling (BWS) is a survey method for assessing individuals' priorities. It identifies the extremes—best and worst items, most and least impor - tant factors, biggest and smallest influences—among sets. In this article, we demonstrate an application of BWS in a primary care setting to illustrate its use in identifying patient priorities for services. METHODS We conducted a BWS survey in 2014 in Boston, Massachusetts, to assess the relative importance of 10 previously identified...
Published on Apr 1, 2016in Journal of Genetic Counseling2.45
Holly Peay14
Estimated H-index: 14
(LEI: Leiden University),
Ilene L. Hollin9
Estimated H-index: 9
(Johns Hopkins University),
John F. P. Bridges27
Estimated H-index: 27
(Johns Hopkins University)
Duchenne muscular dystrophy (DMD) is a progressive, fatal pediatric disorder with significant burden on parents. Assessing disease impact can inform clinical interventions. Best-worst scaling (BWS) was used to elicit parental priorities among 16 short-term, DMD-related worries identified through community engagement. Respondents viewed 16 subsets of worries, identified using a balanced, incomplete block design, and identified the most and least worrying items. Priorities were assessed using best...
Published on Dec 1, 2015in BMC Gastroenterology2.25
Kathleen Yan2
Estimated H-index: 2
(Yale University),
John F. P. Bridges27
Estimated H-index: 27
(Johns Hopkins University)
+ 3 AuthorsLiana Fraenkel31
Estimated H-index: 31
(Yale University)
Background Reasons underlying the variability of physicians’ preferences for non-selective beta-blockers (BBs) and endoscopic variceal ligation (EVL) to prevent a first variceal bleed have not been empirically studied. Our aims were to examine whether 1) gastroenterologists can be classified into distinct subgroups based on how they prioritize specific treatment attributes and 2) physician characteristics are associated with treatment preference.