Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
Abstract
In Alzheimer's disease (AD), β-amyloid (Aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown. Here we show that microglia constitute a barrier with profound impact on plaque composition and toxicity. Using high-resolution confocal and in vivo two-photon imaging in AD mouse models, we demonstrate that this barrier prevents outward plaque expansion and leads to compact plaque microregions...
Paper Details
Title
Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
Published Date
Jan 29, 2015
Journal
Volume
6
Issue
1
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