Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
Abstract
Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.In a collaborative meta-analysis, we studied Asp358Ala (rs2228145) in IL6R in relation to a...
Paper Details
Title
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
Published Date
Mar 1, 2012
Journal
Volume
379
Issue
9822
Pages
1205 - 1213
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