PhyloCSF: a comparative genomics method to distinguish protein coding and non-coding regions
Abstract
As high-throughput transcriptome sequencing provides evidence for novel transcripts in many species, there is a renewed need for accurate methods to classify small genomic regions as protein coding or non-coding. We present PhyloCSF, a novel comparative genomics method that analyzes a multispecies nucleotide sequence alignment to determine whether it is likely to represent a conserved protein-coding region, based on a formal statistical...
Paper Details
Title
PhyloCSF: a comparative genomics method to distinguish protein coding and non-coding regions
Published Date
Jun 14, 2011
Journal
Volume
27
Issue
13
Pages
i275 - i282
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