Progression of Secondary Injury After Musculoskeletal Trauma—A Window of Opportunity?

Context: Acute musculoskeletal-injury management largely focuses on inhibiting secondary injury, although the data describing secondary injury and the timeline for its progression are sparse. Objective: To describe the timeline and early progression of secondary injury in skeletal muscle over the first 5 h after blunt trauma. Design: A controlled laboratory study with 2 independent variables (injury status and postinjury time point) in a 2 × 21...