Cross-Talk Between Notch and EGFR Signaling in Human Breast Cancer Cells
Abstract
Notch and epidermal growth factor receptor (EGFR) signaling play critical roles in cell proliferation, differentiation, and apoptosis, and thereby may contribute to the development of breast cancer. We constitutively overexpressed active Notch1 in human breast cancer cells to explore the consequences of Notch1 signaling on cell growth and to investigate the underlying molecular mechanisms. We found that EGFR expression was increased. Then, using...
Paper Details
Title
Cross-Talk Between Notch and EGFR Signaling in Human Breast Cancer Cells
Published Date
Jan 1, 2009
Journal
Volume
27
Issue
5
Pages
533 - 540
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