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Effect of Iron Supplementation on Development of Iron Deficiency Anemia in Breastfed Infants

Published on Dec 1, 2012in Journal of Tropical Pediatrics1.289
· DOI :10.1093/tropej/fms028
Gülbin Gökçay12
Estimated H-index: 12
(Istanbul University),
Tülin Ayse Özden8
Estimated H-index: 8
(Istanbul University)
+ 4 AuthorsYusuf Sahip6
Estimated H-index: 6
(Istanbul University)
Abstract
This trial aimed to investigate the effect of iron supplementation on the development of iron deficiency anemia. The study encompassed 6-month-old infants who had been exclusively breastfed in the first 4 months of life. Infants in the supplemented group were given 1 mg kg(-1 )day(-1) ferrous sulfate for 6 months starting at 6 months of age. Blood samples were taken at age 12 months. A 3-day-diet was evaluated at 1 year of age. Data of 51 infants in the supplemented and 54 infants in the control group were analyzed. Mean hemoglobin values were similar in the two groups at the age of 12 months. Mean ferritin level of the supplemented group was significantly higher than that of the control. There was a significant positive correlation between dietary iron intake and hemoglobin levels. Nutrition might be more important than iron supplementation in preventing iron deficiency anemia during infancy.
  • References (12)
  • Citations (4)
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References12
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#2Lori Feldman-WinterH-Index: 13
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We have major concerns about universal iron supplementation at 4 months in breastfeeding infants, as recommended by Baker, Greer, and the American Academy of Pediatrics (AAP) Committee on Nutrition.1 We point out that as a clinical recommendation for millions of infants, supplementary iron drops beginning at 4 months of age is inconsistent with previous recommendations from the AAP.2,–,4.The only supportive data for this recommendation come from a study in which …
9 CitationsSource
The authors of the new American Academy of Pediatrics (AAP) recommendations for prevention of iron deficiency and iron-deficiency anemia conclude that “exclusively breastfed term infants [should] receive an iron supplementation of 1 mg/kg per day, starting at 4 months of age.”1 Prevention of iron deficiency and iron-deficiency anemia are important public health goals. However, although late-preterm and low birth weight infants and other infants with risk for low iron stores may benefit from iron...
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#1Camila M. Chaparro (OPS: Pan American Health Organization)H-Index: 1
Iron deficiency is estimated to be the most common nutritional deficiency worldwide and is particularly persistent among infants and children. The high prevalence of anemia in 6- to 9-mo-old children raises the concern that birth iron stores in some infants are inadequate to sustain growth and development through the first 6 mo of life, and postnatal factors are contributing to early depletion of iron stores and development of anemia. At the same time, there are concerns about negative effects o...
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The prevalence of iron deficiency among infants and young children living in developing countries is high. Because of its chemical properties--namely its oxidative potential--iron functions in several biological systems that are crucial to human health. Iron which is not easily eliminated from the body can also cause harm through oxidative stress interference with the absorption or metabolism of other nutrients and suppression of critical enzymatic activities. We reviewed 26 randomized controlle...
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Iron supplements are often prescribed during infancy but their benefits and risks have not been well documented. We examined whether iron supplements affect growth or morbidity of breast-fed infants. Full-term infants in Sweden (n = 101) and Honduras (n = 131) were randomly assigned to three groups at 4 mo of age: 1) placebo from 4 to 9 mo; 2) placebo from 4 to 6 mo and iron supplements [1 mg/(kg. d)] from 6 to 9 mo; or 3) iron supplements from 4 to 9 mo. All infants were exclusively or nearly e...
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Micronutrient deficiencies continue to be widespread among children under-five in low- and middle-income countries (LMICs), despite the fact that several effective strategies now exist to prevent them. This kind of malnutrition can have several immediate and long-term consequences, including stunted growth, a higher risk of acquiring infections, and poor development outcomes, all of which may lead to a child not achieving his or her full potential. This review systematically synthesizes the avai...
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Dogumdan sonra ilk iki yil, optimal buyume ve gelisim icin "kritik pencere" donemidir. Bu donemde, yetersiz beslenme onemli morbilite ve mortalite nedenidir. Anne sutu dogumdan itibaren alti ay sonuna kadar olan donemde, bebegin tum besinsel gereksinimlerine tek basina cevap verebilen mukemmel icerige sahip, dogal bir gidadir. Alti aydan sonra uygun sekilde baslanan ek gidalarla birlikte emzirmeye iki yasin sonuna kadar devam edilmelidir. Zamaninda baslatilan uygun tamamlayici beslenme, sut cocu...
Iron deficiency is the most common nutritional deficiency worldwide and an important public health problem especially in developing countries. Since the most important indicator of iron deficieny is anemia, the terms “iron deficiency” and “iron deficiency anemia” are often used interchangeably. However, iron deficiency may develop in the absence of anemia and the tissues may be affected from this condition. The most common causes of iron deficiency in children include insufficient intake togethe...
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Purpose of reviewIron deficiency early in life is associated with impaired neurological development. This study reviews the latest research on how to best meet iron requirements in infants and chil ...
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