An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations

Introduction: In previous studies, we have shown that a gliclazide–cholic acid derivative (G–CA) mixture resulted in an enhanced ileal permeation of G (ex vivo). When administered orally to diabetic rats, it brought about a significant hypoglycaemic effect. In this study, we aim to create a novel microencapsulated-formulation of G–CA with uniform and coherent structure that can be further tested in our rat model of type 1 diabetes (T1D). We also...