Arterial rupture in classic Ehlers–Danlos syndrome with COL5A1 mutation

The vascular type of Ehlers–Danlos syndrome (EDS IV) is associated with a high risk of life‐threatening medical complications, including ruptures of large arteries, the intestine, and the uterus during pregnancy. An arterial rupture occurring in an individual with EDS is regarded as almost diagnostic of EDS IV, which is caused by heterozygous mutations in COL3A1 . Here however, we report on a man with skin lesions typical of EDS, easy bruising...