Binding of the HIV-1 Nucleocapsid Protein to the Primer tRNALys3, inVitro, Is Essentially Not Specific

Volume: 270, Issue: 4, Pages: 1650 - 1656
Published: Jan 27, 1995
Abstract
The nucleocapsid protein NCp7 of human immunodeficiency virus, type 1, is a key component in the viral life cycle. Since, the first common step of all reported NCp7 activities corresponds to a nucleic acid-binding step, the NCp7 binding parameters to the natural primer tRNA3 were investigated. Using NCp7 intrinsic fluorescence, we found that (i) in 0.1 M NaCl, NCp7 bound noncooperatively to tRNA3 with a K = 3.2 × 106M association constant and a...
Paper Details
Title
Binding of the HIV-1 Nucleocapsid Protein to the Primer tRNALys3, inVitro, Is Essentially Not Specific
Published Date
Jan 27, 1995
Volume
270
Issue
4
Pages
1650 - 1656
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