Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

Volume: 98, Issue: 13, Pages: 7522 - 7527
Published: Jun 19, 2001
Abstract
Insulin resistance in skeletal muscle and liver may play a primary role in the development of type 2 diabetes mellitus, and the mechanism by which insulin resistance occurs may be related to alterations in fat metabolism. Transgenic mice with muscle- and liver-specific overexpression of lipoprotein lipase were studied during a 2-h hyperinsulinemic–euglycemic clamp to determine the effect of tissue-specific increase in fat on insulin action and...
Paper Details
Title
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
Published Date
Jun 19, 2001
Volume
98
Issue
13
Pages
7522 - 7527
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