Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers

Volume: 106, Issue: 12, Pages: 4828 - 4833
Published: Mar 24, 2009
Abstract
Cancers are clonal expansions, but how a single, transformed human cell grows into a billion-cell tumor is uncertain because serial observations are impractical. Potentially, this history is surreptitiously recorded within genomes that become increasingly numerous, polymorphic, and physically separated after transformation. To correlate physical with epigenetic pairwise distances, small 2,000- to 10,000-cell gland fragments were sampled from...
Paper Details
Title
Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers
Published Date
Mar 24, 2009
Volume
106
Issue
12
Pages
4828 - 4833
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