CaM Kinase II mediates maladaptive post‐infarct remodeling and pro‐inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury

Ca MKII was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. Here, we investigated the roles of different Ca MKII isoforms and splice variants in ischemia/reperfusion (I/R) injury by the use of new genetic Ca MKII mouse models. Although Ca MKII δC was upregulated 1 day after I/R injury, cardiac damage 1 day after I/R was neither affected in Ca MKII δ‐deficient mice, Ca MKII δ‐deficient mice in which the splice...