Neuronal activity regulates extracellular tau in vivo
Abstract
Tau is primarily a cytoplasmic protein that stabilizes microtubules. However, it is also found in the extracellular space of the brain at appreciable concentrations. Although its presence there may be relevant to the intercellular spread of tau pathology, the cellular mechanisms regulating tau release into the extracellular space are not well understood. To test this in the context of neuronal networks in vivo, we used in vivo microdialysis....
Paper Details
Title
Neuronal activity regulates extracellular tau in vivo
Published Date
Feb 17, 2014
Volume
211
Issue
3
Pages
387 - 393
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