Match!

The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer

Published on Jan 1, 2000in Pharmacological Reviews18.89
Elliott Middleton32
Estimated H-index: 32
,
Chithan Kandaswami17
Estimated H-index: 17
,
Theoharis C. Theoharides73
Estimated H-index: 73
Abstract
Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil, tea, and red wine. They are low molecular weight compounds composed of a three-ring structure with various substitutions. This basic structure is shared by tocopherols (vitamin E). Flavonoids can be subdivided according to the presence of an oxy group at position 4, a double bond between carbon atoms 2 and 3, or a hydroxyl group in position 3 of the C (middle) ring. These characteristics appear to also be required for best activity, especially antioxidant and antiproliferative, in the systems studied. The particular hydroxylation pattern of the B ring of the flavonoles increases their activities, especially in inhibition of mast cell secretion. Certain plants and spices containing flavonoids have been used for thousands of years in traditional Eastern medicine. In spite of the voluminous literature available, however, Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional. Suggestions are made where such possibilities may be worth pursuing.
Figures & Tables
  • References (987)
  • Citations (3504)
References987
Newest
#1Philip V. Townsend (ANU: Australian National University)H-Index: 1
#2Michael F. Crouch (ANU: Australian National University)H-Index: 19
Last.Andrew J. Hapel (ANU: Australian National University)H-Index: 17
view all 4 authors...
#1Catherine Rice-Evans ('KCL': King's College London)H-Index: 62
#2Lester PackerH-Index: 98
#1Theoharis C. Theoharides (Tufts University)H-Index: 73
#2Phani Patra (Tufts University)H-Index: 4
Last.A Athanasiou (Tufts Medical Center)H-Index: 1
view all 9 authors...
Cited By3504
Newest
#1M. Sánchez (Complutense University of Madrid)H-Index: 17
#2Honorato Ribeiro-Vidal (Complutense University of Madrid)
Last.David Herrera (Complutense University of Madrid)H-Index: 33
view all 8 authors...
#1Panfeng Yao (UGent: Ghent University)H-Index: 1
#2Renyu Deng (Sichuan Agricultural University)H-Index: 2
Last.Qi Wu (Sichuan Agricultural University)H-Index: 12
view all 10 authors...
View next paperPolyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance