Infection of macrophages withMycobacterium tuberculosisinduces global modifications to phagosomal function
Abstract
The phagosome is a central mediator of both the homeostatic and microbicidal functions of a macrophage. Following phagocytosis, Mycobacterium tuberculosis (Mtb) is able to establish infection through arresting phagosome maturation and avoiding the consequences of delivery to the lysosome. The infection of a macrophage by Mtb leads to marked changes in the behaviour of both the macrophage and the surrounding tissue as the bacterium modulates its...
Paper Details
Title
Infection of macrophages withMycobacterium tuberculosisinduces global modifications to phagosomal function
Published Date
Jan 9, 2013
Journal
Volume
15
Issue
6
Pages
843 - 859
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