Developing a Clinically Feasible Personalized Medicine Approach to Pediatric Septic Shock

Rationale: Using microarray data, we previously identified gene expression–based subclasses of septic shock with important phenotypic differences. The subclass-defining genes correspond to adaptive immunity and glucocorticoid receptor signaling. Identifying the subclasses in real time has theranostic implications, given the potential for immune-enhancing therapies and controversies surrounding adjunctive corticosteroids for septic...