Original paper

Thrombin Upregulates Tissue Transglutaminase in Endothelial Cells

Volume: 21, Issue: 10, Pages: 1689 - 1694
Published: Oct 1, 2001
Abstract
Atherosclerosis is characterized by thickening of the vessel wall, smooth muscle cell proliferation, macrophage infiltration, and deposition of a fibrin network. Transglutaminases are a family of enzymes catalyzing the formation of stable covalent cross-links between proteins. Here, we show that tissue transglutaminase (tTG) synthesis by human umbilical vein endothelial cells is upregulated by thrombin, the serine protease that causes fibrin...
Paper Details
Title
Thrombin Upregulates Tissue Transglutaminase in Endothelial Cells
Published Date
Oct 1, 2001
Volume
21
Issue
10
Pages
1689 - 1694
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