The Lin28/let-7 axis regulates glucose metabolism

Cell64.50
Volume: 147, Issue: 1, Pages: 81 - 94
Published: Sep 30, 2011
Abstract
The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We have uncovered unexpected roles for the Lin28/let-7 pathway in regulating metabolism. When overexpressed in mice, both Lin28a and LIN28B promote an insulin-sensitized state that resists high-fat-diet induced diabetes. Conversely, muscle-specific loss of Lin28a or...
Paper Details
Title
The Lin28/let-7 axis regulates glucose metabolism
Published Date
Sep 30, 2011
Journal
Volume
147
Issue
1
Pages
81 - 94
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.