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α-Glucosidase and α-amylase inhibitors from Myrcia spp.: a stronger alternative to acarbose?

Published on Jan 1, 2016in Journal of Pharmaceutical and Biomedical Analysis2.983
· DOI :10.1016/j.jpba.2015.10.042
María Figueiredo-González4
Estimated H-index: 4
(University of Porto),
Clara Grosso20
Estimated H-index: 20
(University of Porto)
+ 1 AuthorsPaula B. Andrade58
Estimated H-index: 58
(University of Porto)
Sources
Abstract
Abstract “Pedra hume caa” is the common name of five species of Myrcia genus used as traditional medicine for the treatment of diabetes mellitus. In this study, different extracts from Myrcia salicifolia , Myrcia sphaerocarpa , and Myrcia speciosa were investigated for the first time, to identify their phenolic compounds (being 3- O -rhamnoside derivatives of myricetin and quercetin the major ones) and in vitro inhibitory potential against α-glucosidase and α-amylase. These extracts inhibited 90–500 times more α-glucosidase (IC 50  = 0.7 to 4.1 μg ml −1 ) than acarbose and displayed a mild inhibition against α-amylase (IC 50  = 6.1 to 29 μg mL −1 ).
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