Original paper
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
Abstract
Alternative (M2) activation of macrophages driven via the α-chain of the receptor for interleukin 4 (IL-4Rα) is important for immunity to parasites, wound healing, the prevention of atherosclerosis and metabolic homeostasis. M2 polarization is dependent on fatty acid oxidation (FAO), but the source of the fatty acids that support this metabolic program has not been clear. We found that the uptake of triacylglycerol substrates via the scavenger...
Paper Details
Title
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
Published Date
Aug 3, 2014
Journal
Volume
15
Issue
9
Pages
846 - 855
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Notes
History