Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate
Abstract
Metabolism is influenced by age, food intake, and conditions such as diabetes and obesity. How do physiological or pathological metabolic changes influence stem cells, which are crucial for tissue homeostasis? This Commentary reviews recent evidence that stem cells have different metabolic demands than differentiated cells, and that the molecular mechanisms that control stem cell self-renewal and differentiation are functionally connected to the...
Paper Details
Title
Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate
Published Date
Dec 1, 2012
Journal
Volume
125
Issue
23
Pages
5597 - 5608
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Notes
History