WU-CRISPR: characteristics of functional guide RNAs for the CRISPR/Cas9 system
Abstract
The CRISPR/Cas9 system has been rapidly adopted for genome editing. However, one major issue with this system is the lack of robust bioinformatics tools for design of single guide RNA (sgRNA), which determines the efficacy and specificity of genome editing. To address this pressing need, we analyze CRISPR RNA-seq data and identify many novel features that are characteristic of highly potent sgRNAs. These features are used to develop a...
Paper Details
Title
WU-CRISPR: characteristics of functional guide RNAs for the CRISPR/Cas9 system
Published Date
Nov 2, 2015
Journal
Volume
16
Issue
1
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