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Plasma Phospholipid Trans‐Fatty Acids Levels, Cardiovascular Diseases, and Total Mortality: The Cardiovascular Health Study

Published on Aug 15, 2014in Journal of the American Heart Association4.66
· DOI :10.1161/JAHA.114.000914
Qianyi Wang4
Estimated H-index: 4
(Harvard University),
Fumiaki Imamura27
Estimated H-index: 27
(University of Cambridge)
+ 6 AuthorsDariush Mozaffarian120
Estimated H-index: 120
Abstract
Background While self-reported trans– fatty acid (TFA) consumption is linked to coronary heart disease (CHD), relationships between objective biomarkers of TFA subtypes ( t- 16:1n9, total t- 18:1, and cis / trans- ( c / t- ), t / c- and t / t- 18:2) and cardiovascular disease (CVD) or total mortality are not well established. Methods and Results We evaluated 2742 adults in the Cardiovascular Health Study, aged 74±5 years and free of prevalent CVD, with plasma phospholipid TFA measures in 1992. Incident fatal and nonfatal CHD events, CVD and non-CVD mortality, and total mortality were centrally adjudicated through 2010. Risks were assessed using Cox proportional hazards. During 31 494 person-years, 1735 total deaths and 639 total CHD events occurred. In the multivariate model including mutual adjustment for the 5 TFA subtypes, circulating t / t- 18:2 was associated with higher total mortality (extreme quintile hazard ratio (HR)=1.23, 95% CI=1.04 to 1.44, P -trend=0.01), CVD mortality (HR=1.40, 95% CI=1.05 to 1.86, P -trend=0.02), and total CHD (HR=1.39, 95% CI=1.06 to 1.83, P -trend=0.01). t / c- 18:2 was positively related to total mortality (HR=1.19, P -trend=0.05), total CHD (HR=1.67, P -trend=0.002), and nonfatal CHD (HR=2.06, P -trend=0.002) after mutual adjustment; these associations were insignificant without mutual adjustment. Neither t- 16:1n9 nor t- 18:1 was significantly associated with total mortality or CVD, nor was c / t -18:2 if we excluded early cases. Conclusions Among circulating TFAs, t / t- 18:2 was most adversely associated with total mortality, mainly due to the increased risk of CVD. t / c- 18:2 was also positively associated with total mortality and CHD, but only after adjustment for other TFAs. These results highlight the need for further investigation of dietary sources, nondietary determinants, and health effects of specific TFA subtypes, especially t -18:2 isomers.
  • References (62)
  • Citations (36)
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References62
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Objective India has proposed legislating an upper limit of trans fat in partially hydrogenated vegetable oils and mandating trans fat labelling in an effort to reduce intakes. The objective of the present study was to examine the complexities of regulating trans fat in India by examining the policy processes involved and the perceived implementation challenges. Design Semi-structured interviews ( n 18) were conducted with key informants from various sectors. Interviewees were asked about sources...
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#1Dariush Mozaffarian (Harvard University)H-Index: 120
#2Marcia C. de Oliveira Otto (Harvard University)H-Index: 13
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140 CitationsSource
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Trans fatty acids (TFA) are reported to contribute to inflammation and coronary heart disease. The study aim was to investigate the proapoptotic effects of two double bond TFA (TDTFA) on human umbilical vein endothelial cells (HUVEC). The HUVEC were grown in media supplied with linoelaidic acid (9t,12t-C18:2) at 50, 100, 200, 400 μmol/l for 24 or 48 h to examine the effects of TDTFA on the viability and apoptosis of these cells. Flow cytometry analysis and confocal scanning were used to measure ...
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