Inhibitory effect of CuSO4 on α-glucosidase activity in ddY mice

We investigated the effects of divalent alkaline earth and first-row transition metal and zinc ions on α-glucosidase activityin vitro and in vivo. CuSO4 and ZnSO4 exhibited a high α-glucosidase inhibitory effect in vitro. The IC50 values of CuSO4 were 0.77 ± 0.01 (substrate; maltose) and 0.78 ± 0.01 (substrate; sucrose), and those of ZnSO4 were 5.49 ± 0.14 (substrate; maltose) and 4.70 ± 0.06 (substrate; sucrose) for yeast α-glucosidase. On the...