Original paper
Inhibition of JNK activation through NF-κB target genes
Abstract
The proinflammatory cytokine tumour necrosis factor-alpha (TNF-alpha) regulates immune responses, inflammation and programmed cell death (apoptosis). The ultimate fate of a cell exposed to TNF-alpha is determined by signal integration between its different effectors, including IkappaB kinase (IKK), c-Jun N-terminal protein kinase (JNK) and caspases. Activation of caspases is required for apoptotic cell death, whereas IKK activation inhibits...
Paper Details
Title
Inhibition of JNK activation through NF-κB target genes
Published Date
Nov 1, 2001
Journal
Volume
414
Issue
6861
Pages
313 - 317
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Notes
History