Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding
Abstract
Hypochlorous acid (HOCl), the active ingredient in household bleach, is an effective antimicrobial produced by the mammalian host defense to kill invading microorganisms. Despite the widespread use of HOCl, surprisingly little is known about its mode of action. In this study, we demonstrate that low molar ratios of HOCl to protein cause oxidative protein unfolding in vitro and target thermolabile proteins for irreversible aggregation in vivo. As...
Paper Details
Title
Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding
Published Date
Nov 1, 2008
Journal
Volume
135
Issue
4
Pages
691 - 701
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