Giardia duodenalis Cathepsin B Proteases Degrade Intestinal Epithelial Interleukin-8 and Attenuate Interleukin-8-Induced Neutrophil Chemotaxis

Giardia duodenalis (syn. G. intestinalis , G. lamblia ) infections are a leading cause of waterborne diarrheal disease that can also result in the development of postinfectious functional gastrointestinal disorders via mechanisms that remain unclear. Parasite numbers exceed 10 6 trophozoites per centimeter of gut at the height of an infection. Yet the intestinal mucosa of G. duodenalis -infected individuals is devoid of signs of overt...