Original paper
Muscle-specific Pparg deletion causes insulin resistance
Abstract
Thiazolidinediones (TZDs) are insulin-sensitizing drugs and are potent agonists of the nuclear peroxisome proliferator-activated receptor-gamma (PPAR-gamma). Although muscle is the major organ responsible for insulin-stimulated glucose disposal, PPAR-gamma is more highly expressed in adipose tissue than in muscle. To address this issue, we used the Cre-loxP system to knock out Pparg, the gene encoding PPAR-gamma, in mouse skeletal muscle. As...
Paper Details
Title
Muscle-specific Pparg deletion causes insulin resistance
Published Date
Nov 16, 2003
Journal
Volume
9
Issue
12
Pages
1491 - 1497
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Notes
History