Match!

Attack rates assessment of the 2009 pandemic H1N1 influenza A in children and their contacts: a systematic review and meta-analysis.

Published on Nov 30, 2012in PLOS ONE2.776
· DOI :10.1371/journal.pone.0050228
Aharona Glatman-Freedman2
Estimated H-index: 2
(NYU: New York University),
Ian Portelli9
Estimated H-index: 9
(NYU: New York University)
+ 4 AuthorsSilas W. Smith14
Estimated H-index: 14
(NYU: New York University)
Abstract
Background The recent H1N1 influenza A pandemic was marked by multiple reports of illness and hospitalization in children, suggesting that children may have played a major role in the propagation of the virus. A comprehensive detailed analysis of the attack rates among children as compared with their contacts in various settings is of great importance for understanding their unique role in influenza pandemics. Methodology/Principal Findings We searched MEDLINE (PubMed) and Embase for published studies reporting outbreak investigations with direct measurements of attack rates of the 2009 pandemic H1N1 influenza A among children, and quantified how these compare with those of their contacts. We identified 50 articles suitable for review, which reported school, household, travel and social events. The selected reports and our meta-analysis indicated that children had significantly higher attack rates as compared to adults, and that this phenomenon was observed for both virologically confirmed and clinical cases, in various settings and locations around the world. The review also provided insight into some characteristics of transmission between children and their contacts in the various settings. Conclusion/Significance The consistently higher attack rates of the 2009 pandemic H1N1 influenza A among children, as compared to adults, as well as the magnitude of the difference is important for understanding the contribution of children to disease burden, for implementation of mitigation strategies directed towards children, as well as more precise mathematical modeling and simulation of future influenza pandemics.
  • References (64)
  • Citations (28)
📖 Papers frequently viewed together
220 Citations
40 Citations
1 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References64
Newest
#1Lincoln L. H. LauH-Index: 11
#2Hiroshi Nishiura (HKU: University of Hong Kong)H-Index: 36
Last. Benjamin J. CowlingH-Index: 47
view all 6 authors...
In 2009 influenza A (H1N1-2009) virus (abbreviated as pH1N1) emerged to cause the first influenza pandemic of the 21st Century.1 Many epidemiologic studies were carried out to characterize the epidemiology of pH1N1 and inform decisions about possible countermeasures. Of particular early interest was the frequency of transmission from confirmed cases to their close contacts. The household, defined as a person or a group of people living in the same residence, provides a strategic setting to track...
42 CitationsSource
#1Nimalan Arinaminpathy (Princeton University)H-Index: 19
#2N. Raphaely (HPA: Health Protection Agency)H-Index: 1
Last. Noel D. McCarthy (HPA: Health Protection Agency)H-Index: 36
view all 7 authors...
A pandemic influenza A(H1N1) 2009 outbreak in a summer school affected 117/276 (42%) students. Residential social contact was associated with risk of infection, and there was no evidence for transmission associated with the classroom setting. Although the summer school had new admissions each week, which provided susceptible students the outbreak was controlled using routine infection control measures (isolation of cases, basic hygiene measures and avoidance of particularly high-risk social even...
4 CitationsSource
#1Ville Peltola (UTU: University of Turku)H-Index: 31
#2Tamara Teros-Jaakkola (UTU: University of Turku)H-Index: 2
Last. Jussi Mertsola (UTU: University of Turku)H-Index: 46
view all 7 authors...
Please cite this paper as: Peltola et al. (2011) Pandemic influenza A (H1N1) virus in households with young children. Influenza and Other Respiratory Viruses 6(3), e21–e24. Abstract Background Influenza viruses may cause a severe infection in infants and young children. The transmission patterns of pandemic 2009 influenza A (H1N1) within households with young children are poorly characterized. Methods Household members of six children younger than 1·5 years with documented 2009 influenza A (H1N1...
5 CitationsSource
AbstractThe investigation of clustered cases of pandemic A/H1N1 2009 influenza virus infection (21 children, 3 adults) during a summer camp, led to the identification of transportation as the circumstance of transmission. Results suggest that super-spreading of flu can occur in a confined space without sufficient air renewal.
8 CitationsSource
#1Nobuo HirotsuH-Index: 2
#2Koji WadaH-Index: 17
Last. Hitoshi OshitaniH-Index: 27
view all 3 authors...
BACKGROUND: Household transmission of influenza can affect the daily lives of patients and their families and be a trigger for community transmission, thus it is necessary to take precautions to prevent household transmission. We aimed to determine the risks of household transmission of pandemic (H1N1) 2009 influenza virus from an index patient who visited a primary clinic and was treated with antiviral drugs. METHODS: We followed up all the patients who were diagnosed with influenza A by rapid ...
8 CitationsSource
#1Xinghuo PangH-Index: 12
#2Peng YangH-Index: 17
Last. Quanyi WangH-Index: 20
view all 12 authors...
We estimated the attack rate of pandemic (H1N1) 2009 and assessed risk factors for infection among close contacts quarantined in Beijing, People’s Republic of China. The first 613 confirmed cases detected between May 16 and September 15, 2009, were investigated; 7,099 close contacts were located and quarantined. The attack rate of confirmed infection in close contacts was 2.4% overall, ranging from 0.9% among aircraft passengers to >5% among household members. Risk factors for infection among cl...
12 CitationsSource
#1Luan-Yin ChangH-Index: 40
#2Wei-Hua ChenH-Index: 2
Last. Li-Min HuangH-Index: 46
view all 7 authors...
During August–November 2009, to investigate disease transmission within households in Taiwan, we recruited 87 pandemic (H1N1) 2009 patients and their household members. Overall, pandemic (H1N1) 2009 virus was transmitted to 60 (27%) of 223 household contacts. Transmission was 4× higher to children than to adults (61% vs. 15%; p<0.001).
12 CitationsSource
#1Caroline van Gemert (Burnet Institute)H-Index: 10
#2Margaret Hellard (Alfred Hospital)H-Index: 50
Last. Isabel Bergeri (Burnet Institute)H-Index: 7
view all 9 authors...
To examine intrahousehold secondary transmission of pandemic (H1N1) 2009 virus in households in Victoria, Australia, we conducted a retrospective cross-sectional study in late 2009. We randomly selected case-patients reported during May–June 2009 and their household contacts. Information collected included household characteristics, use of prevention and control measures, and signs and symptoms. Secondary cases were defi ned as infl uenza-like illness in household contacts within the specifi ed ...
11 CitationsSource
#1Michael L. Jackson (CDC: Centers for Disease Control and Prevention)H-Index: 2
#3Kathy Hancock (CDC: Centers for Disease Control and Prevention)H-Index: 27
Last. Stephanie J. Schrag (CDC: Centers for Disease Control and Prevention)H-Index: 47
view all 13 authors...
BACKGROUND: Understanding transmissibility of influenza viruses within households is critical for guiding public health response to pandemics. We studied serologically confirmed infection and disease among household contacts of index case patients with 2009 pandemic influenza A (H1N1) virus (pH1N1) infection in a setting of minimal community pH1N1 transmission. METHODS: We defined index case patients as students and staff of a New York City high school with laboratory-confirmed pH1N1 infection d...
25 CitationsSource
#1Richard PebodyH-Index: 51
#2Ross HarrisH-Index: 34
Last. John M WatsonH-Index: 34
view all 24 authors...
The United Kingdom implemented a containment strategy for pandemic (H1N1) 2009 through administering antiviral agents (AVs) to patients and their close contacts. This observational household cohort study describes the effect of AVs on household transmission. We followed 285 confirmed primary cases in 259 households with 761 contacts. At 2 weeks, the confirmed secondary attack rate (SAR) was 8.1% (62/761) and significantly higher in persons 50 years of age (18.9% vs. 1.2%, p<0.001). Early (<48 ho...
34 CitationsSource
Cited By28
Newest
#1Yen-Ta Huang (TCU: Tzu Chi University)H-Index: 1
#2Yu-Kang Tu (NTU: National Taiwan University)
Last. Pei-Chun Lai (TCU: Tzu Chi University)H-Index: 1
view all 3 authors...
Abstract Crude secondary attack rate (SAR) of COVID-19 in Taiwan was 0.84% using nationwide contact-tracing data till April 8, 2020. The random-effect Bayesian metaanalysis yielded 95% credible intervals of 0.42%-1.69% and 0.08%-8.32%, respectively, for estimated SAR pooling from 15 case series and for predicted SAR in the future if pandemic continues.
1 CitationsSource
#1Aharona Glatman-Freedman (TAU: Tel Aviv University)H-Index: 4
#1Aharona Glatman-Freedman (TAU: Tel Aviv University)H-Index: 5
Last. Michal MandelboimH-Index: 20
view all 10 authors...
Background: Influenza A (H3N2) clade 3C.3a was the predominant influenza virus in Israel throughout the 2018-2019 season, constituting a drift from the influenza A (H3N2) vaccine. We estimated the end-of season vaccine effectiveness (VE) by age, among community patients with influenza-like illness (ILI), considering the hemagglutinin (HA) gene mutations and amino acid substitutions of influenza A (H3N2) viruses detected. Methods: Nose-throat samples were analyzed for the presence of influenza vi...
Source
#1David J. Haw (Imperial College London)H-Index: 1
#2Derek A. T. Cummings (UF: University of Florida)H-Index: 44
Last. Steven Riley (Imperial College London)H-Index: 41
view all 6 authors...
Infectious disease transmission in animals is an inherently spatial process in which a host’s home location and their social mixing patterns are important, with the mixing of infectious individuals often different to that of susceptible individuals. Although incidence data for humans have traditionally been aggregated into low-resolution data sets, modern representative surveillance systems such as electronic hospital records generate high volume case data with precise home locations. Here, we u...
1 CitationsSource
Abstract The characteristics of influenza might vary depending on the disease subtype. This review includes previous studies on the transmissibility and severity of influenza and summarizes them by subtype. The attack rate and incubation period of influenza A were 2.3–12.3% and 1.4 days, respectively, and those of influenza B were 0.6–5.5% and 0.6 days, respectively. The five subtypes of influenza A virus, namely, H1N1, H2N2, H3N3, H5N1, and H7N9, are reviewed. The indexes related to transmissib...
2 CitationsSource
#1Lori Uscher-Pines (AN: RAND Corporation)H-Index: 20
#2Heather L. Schwartz (AN: RAND Corporation)H-Index: 10
Last. Amra UzicaninH-Index: 11
view all 7 authors...
Background During an evolving influenza pandemic, community mitigation strategies, such as social distancing, can slow down virus transmission in schools and surrounding communities. To date, research on school practices to promote social distancing in primary and secondary schools has focused on prolonged school closure, with little attention paid to the identification and feasibility of other more sustainable interventions. To develop a list and typology of school practices that have been prop...
2 CitationsSource
#1Catherine King (Children's Hospital at Westmead)H-Index: 9
#2Maria Y. K. Chow (USYD: University of Sydney)H-Index: 1
Last. Julie Leask (USYD: University of Sydney)H-Index: 27
view all 4 authors...
Background Effective public health messaging is essential in both the planning phase and duration of a pandemic. Objectives This study aimed to gain an understanding of parental information seeking, trusted sources and needs in relation to pandemic influenza A 2009 (pH1N1) to inform future policy planning and resource development. Patients/Methods We conducted a mixed methods study; parents from 16 childcare centres in Sydney, Australia, were surveyed between 16 November and 9 December 2009, and...
1 CitationsSource
#1Hélène Pasquini-Descomps (University of Geneva)H-Index: 1
#2Nathalie Brender (University of Applied Sciences Western Switzerland)H-Index: 1
Last. David Maradan (University of Geneva)H-Index: 2
view all 3 authors...
Abstract Background The 2009 A/H1N1 influenza pandemic generated additional data and triggered new studies that opened debate over the optimal strategy for handling a pandemic. The lessons-learned documents from the World Health Organization show the need for a cost estimation of the pandemic response during the risk-assessment phase. Several years after the crisis, what conclusions can we draw from this field of research? Objective The main objective of this article was to provide an analysis o...
2 CitationsSource
#1Timothy R. Shope (University of Pittsburgh)H-Index: 11
#2Benjamin H. Walker (MSU: Mississippi State University)H-Index: 2
Last. Judith M. Martin (University of Pittsburgh)H-Index: 19
view all 6 authors...
BACKGROUND: Children in child care centers represent an important population to consider in attempts to mitigate the spread of an influenza pandemic. This national survey, conducted in 2008 and 2016, assessed directors’ reports of their child care centers’ pandemic influenza preparation before and after the 2009 H1N1 novel influenza pandemic. METHODS: This was a telephone-based survey of child care center directors randomly selected from a national database of licensed US child care centers who ...
Source
#1Suchitra RaoH-Index: 11
#2Kevin MessacarH-Index: 17
Last. Samuel R. DominguezH-Index: 28
view all 13 authors...
In 2014, the Unites States experienced an outbreak of enterovirus D68 associated with severe respiratory illness. The clinical characteristics associated with severe illness from enterovirus D68 during this outbreak compared with those associated with the 2009 H1N1 influenza virus outbreak are unknown.In this retrospective cohort study, we characterized the clinical features of children with enterovirus D68 admitted to the PICU between August 1, 2014, and November 1, 2014, and compared them with...
12 CitationsSource
#1Nicola Principi (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 49
#2Susanna Esposito (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 50
ABSTRACTIntroduction: The identification of factors that can predispose to the development of severe influenza is essential to enable the implementation of optimal prevention and control measures for vulnerable populations.Areas covered: Unfortunately, data in the pediatric age group remain difficult to interpret. However, epidemiological data seem to suggest that the most severe influenza cases, those who are hospitalized, those who are admitted to the intensive care unit, and those who died, o...
4 CitationsSource