The synthesis of (−)-Ambrox® starting from labdanolic acid
Abstract
Iododecarboxylation of labdanolic acid (1), followed by dehydrohalogenation led to alkenes 4 and 12. Both compounds were converted into (1R,2R,4aS,8aS)-1-(2-hydroxyethyl)-2,5,5,8a-tetramethyldecahydro-2-naphthalenol (8), which was transformed via cyclization into (−)-Ambrox®...
Paper Details
Title
The synthesis of (−)-Ambrox® starting from labdanolic acid
Published Date
Jun 1, 2001
Journal
Volume
57
Issue
26
Pages
5657 - 5662
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