Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast
Abstract
DNA replication of eukaryotic chromosomes initiates at a number of discrete loci, called replication origins. Distribution and regulation of origins are important for complete duplication of the genome. Here, we determined locations of Orc1 and Mcm6, components of pre-replicative complex (pre-RC), on the whole genome of Schizosaccharomyces pombe using a high-resolution tiling array. Pre-RC sites were identified in 460 intergenic regions, where...
Paper Details
Title
Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast
Published Date
Feb 15, 2007
Journal
Volume
26
Issue
5
Pages
1327 - 1339
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