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Development, Regeneration, and Evolution of Feathers

Published on Feb 16, 2015in Annual Review of Animal Biosciences 6.78
· DOI :10.1146/annurev-animal-022513-114127
Chih-Feng Chen15
Estimated H-index: 15
(NCHU: National Chung Hsing University),
John Foley19
Estimated H-index: 19
+ 5 AuthorsCheng-Ming Chuong61
Estimated H-index: 61
(SC: University of Southern California)
Abstract
The feather is a complex ectodermal organ with hierarchical branching patterns. It provides functions in endothermy, communication, and flight. Studies of feather growth, cycling, and health are of fundamental importance to avian biology and poultry science. In addition, feathers are an excellent model for morphogenesis studies because of their accessibility, and their distinct patterns can be used to assay the roles of specific molecular pathways. Here we review the progress in aspects of development, regeneration, and evolution during the past three decades. We cover the development of feather buds in chicken embryos, regenerative cycling of feather follicle stem cells, formation of barb branching patterns, emergence of intrafeather pigmentation patterns, interplay of hormones and feather growth, and the genetic identification of several feather variants. The discovery of feathered dinosaurs redefines the relationship between feathers and birds. Inspiration from biomaterials and flight research further ...
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  • Citations (40)
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References151
Newest
Published on Aug 28, 2014in PLOS Genetics 5.54
Chungang Feng10
Estimated H-index: 10
(CAU: China Agricultural University),
Yu Gao10
Estimated H-index: 10
(CAU: China Agricultural University)
+ 18 AuthorsZhao Y6
Estimated H-index: 6
(CAU: China Agricultural University)
Silky-feather has been selected and fixed in some breeds due to its unique appearance. This phenotype is caused by a single recessive gene (hookless, h). Here we map the silky-feather locus to chromosome 3 by linkage analysis and subsequently fine-map it to an 18.9 kb interval using the identical by descent (IBD) method. Further analysis reveals that a C to G transversion located upstream of the prenyl (decaprenyl) diphosphate synthase, subunit 2 (PDSS2) gene is causing silky-feather. All silky-...
14 Citations Source Cite
Published on Mar 1, 2014in Developmental Biology 3.26
Qiqi Chu3
Estimated H-index: 3
(FZU: Fuzhou University),
Linyan Cai2
Estimated H-index: 2
(FZU: Fuzhou University)
+ 9 AuthorsCheng-Ming Chuong61
Estimated H-index: 61
(SC: University of Southern California)
Avian feathers have robust growth and regeneration capability. To evaluate the contribution of signaling molecules and pathways in these processes, we profiled gene expression in the feather follicle using an absolute quantification approach. We identified hundreds of genes that mark specific components of the feather follicle: the dermal papillae (DP) which controls feather regeneration and axis formation, the pulp mesenchyme (Pp) which is derived from DP cells and nourishes the feather follicl...
15 Citations Source Cite
Published on Jan 1, 2014in Frontiers in Endocrinology 3.52
Ai Shinomiya2
Estimated H-index: 2
(National Institute for Basic Biology, Japan),
Tsuyoshi Shimmura5
Estimated H-index: 5
(National Institute for Basic Biology, Japan)
+ 1 AuthorsTakashi Yoshimura35
Estimated H-index: 35
(Nagoya University)
Organisms living outside the tropics measure the changes in the length of the day to adapt to seasonal changes in the environment. Animals that breed during spring and summer are called long-day breeders, while those that breed during fall are called short-day breeders. Although the influence of thyroid hormone in the regulation of seasonal reproduction has been known for several decades, its precise mechanism remained unknown. Recent studies revealed that the activation of thyroid hormone withi...
19 Citations Source Cite
Published on Sep 1, 2013in Journal of Experimental Zoology 2.43
Matthew J. Greenwold7
Estimated H-index: 7
(USC: University of South Carolina),
Roger H. Sawyer30
Estimated H-index: 30
(USC: University of South Carolina)
The archosauria consist of two living groups, crocodilians, and birds. Here we compare the structure, expression, and phylogeny of the beta (β)-keratins in two crocodilian genomes and two avian genomes to gain a better understanding of the evolutionary origin of the feather β-keratins. Unlike squamates such as the green anole with 40 β-keratins in its genome, the chicken and zebra finch genomes have over 100 β-keratin genes in their genomes, while the American alligator has 20 β-keratin genes, a...
30 Citations Source Cite
Published on Aug 1, 2013in Frontiers in Neuroendocrinology 6.88
Takashi Yoshimura35
Estimated H-index: 35
Abstract Organisms living outside the tropics use changes in photoperiod to adapt to seasonal changes in the environment. Several models have contributed to an understanding of this mechanism at the molecular and endocrine levels. Subtropical birds are excellent models for the study of these mechanisms because of their rapid and dramatic response to changes in photoperiod. Studies of birds have demonstrated that light is perceived by a deep brain photoreceptor and long day-induced thyrotropin (T...
54 Citations Source Cite
Published on Jul 1, 2013in Genome Biology and Evolution 3.94
Wen-Lang Fan6
Estimated H-index: 6
(AS: Academia Sinica),
Chen Siang Ng9
Estimated H-index: 9
(AS: Academia Sinica)
+ 11 AuthorsChi-Tang Mao4
Estimated H-index: 4
(AS: Academia Sinica)
Domestic chickens are excellent models for investigating the genetic basis of phenotypic diversity, as numerous phenotypic changes in physiology, morphology, and behavior in chickens have been artificially selected. Genomic study is required to study genome-wide patterns of DNA variation for dissecting the genetic basis of phenotypic traits. We sequenced the genomes of the Silkie and the Taiwanese native chicken L2 at ∼23- and 25-fold average coverage depth, respectively, using Illumina sequenci...
35 Citations Source Cite
Published on Jun 21, 2013in Science 41.06
Sung-Jan Lin31
Estimated H-index: 31
,
John Foley19
Estimated H-index: 19
(IU: Indiana University)
+ 11 AuthorsChih-Feng Chen15
Estimated H-index: 15
(NCHU: National Chung Hsing University)
Color patterns of bird plumage affect animal behavior and speciation. Diverse patterns are present in different species and within the individual. Here, we study the cellular and molecular basis of feather pigment pattern formation. Melanocyte progenitors are distributed as a horizontal ring in the proximal follicle, sending melanocytes vertically up into the epithelial cylinder which gradually emerges as feathers grow. Different pigment patterns form by modulating the presence, arrangement, or ...
49 Citations Source Cite
Ang Li8
Estimated H-index: 8
(SC: University of Southern California),
Meng Chen1
Estimated H-index: 1
(UCI: University of California, Irvine)
+ 4 AuthorsCheng-Ming Chuong61
Estimated H-index: 61
(SC: University of Southern California)
Abstract How organs are shaped to specific forms is a fundamental issue in developmental biology. To address this question, we used the repetitive, periodic pattern of feather morphogenesis on chicken skin as a model. Avian feathers within a single tract extend from dome-shaped primordia to thin conical structures with a common axis of orientation. From a systems biology perspective, the process is precise and robust. Using tissue transplantation assays, we demonstrate that a “zone of polarizing...
21 Citations Source Cite
Published on Apr 1, 2013in Gene 2.50
Li Zhang6
Estimated H-index: 6
(GDOU: Guangdong Ocean University),
Qinghua Nie17
Estimated H-index: 17
(SCAU: South China Agricultural University)
+ 4 AuthorsXiquan Zhang19
Estimated H-index: 19
(SCAU: South China Agricultural University)
Abstract Skin acts an important protection role in animal survival and it evolves with the animal divergence. We identified the conserved miRNA families of skin among duck and other species. Cluster analysis showed that the species with similar skin characteristics were clustered into the same group, indicating miRNAs are important in skin function and skin evolution. The miRNA profiles demonstrated that different miRNA regulation mechanism may exist in contour feather follicles (with the surrou...
19 Citations Source Cite
Published on Feb 28, 2013in PLOS ONE 2.77
Nicola Saino53
Estimated H-index: 53
(University of Milan),
Maria Romano30
Estimated H-index: 30
(University of Milan)
+ 5 AuthorsKazumasa Wakamatsu62
Estimated H-index: 62
(RMIT: RMIT University)
Melanin is the main pigment in animal coloration and considerable variation in the concentrations of the two melanin forms (pheo- and eumlanin) in pigmented tissues exists among populations and individuals. Melanin-based coloration is receiving increasing attention particularly in socio-sexual communication contexts because the melanocortin system has been hypothesized to provide a mechanistic basis for covariation between coloration and fitness traits. However, with few notable exceptions, litt...
40 Citations Source Cite
Cited By40
Newest
Published on Apr 29, 2019in Protoplasma 2.46
Julia Lachner3
Estimated H-index: 3
,
Florian Ehrlich1
Estimated H-index: 1
+ 4 AuthorsLeopold Eckhart29
Estimated H-index: 29
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Published on Apr 1, 2019in Ecotoxicology 1.99
Asfa Rizvi4
Estimated H-index: 4
(AMU: Aligarh Muslim University),
Bilal Ahmed6
Estimated H-index: 6
(AMU: Aligarh Muslim University)
+ 1 AuthorsMohd. Saghir Khan4
Estimated H-index: 4
(AMU: Aligarh Muslim University)
Heavy metal pollution destruct soil microbial compositions and functions, plant’s performance and subsequently human health. Culturable microbes among many metal abatement strategies are considered inexpensive, viable and environmentally safe. In this study, nitrogen fixing bacterial strain CAZ3 recovered from chilli rhizosphere tolerated 100, 1000 and 1200 µg mL−1 of cadmium, chromium and nickel, respectively and was identified as Azotobacter chroococcum by 16S rDNA sequence analysis. Under met...
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Published on Apr 1, 2019in Experimental Dermatology 2.61
QingXiang Gao1
Estimated H-index: 1
(FZU: Fuzhou University),
Guixuan Zhou4
Estimated H-index: 4
(FZU: Fuzhou University)
+ 2 AuthorsZhiCao Yue1
Estimated H-index: 1
(UM: University of Miami)
1 Citations Source Cite
Published on Apr 1, 2019in Experimental Dermatology 2.61
Maksim V. Plikus26
Estimated H-index: 26
,
Cheng-Ming Chuong61
Estimated H-index: 61
(SC: University of Southern California)
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Published on Jan 1, 2019in Nature Ecology and Evolution
Zixiao Yang1
Estimated H-index: 1
(NU: Nanjing University),
Baoyu Jiang13
Estimated H-index: 13
(NU: Nanjing University)
+ 6 AuthorsMichael J. Benton66
Estimated H-index: 66
(UoB: University of Bristol)
Pterosaurs were the first vertebrates to achieve true flapping flight, but in the absence of living representatives, many questions concerning their biology and lifestyle remain unresolved. Pycnofibres—the integumentary coverings of pterosaurs—are particularly enigmatic: although many reconstructions depict fur-like coverings composed of pycnofibres, their affinities and function are not fully understood. Here, we report the preservation in two anurognathid pterosaur specimens of morphologically...
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Published on Jan 1, 2019in Development Growth & Differentiation 1.50
Randall B. Widelitz40
Estimated H-index: 40
(SC: University of Southern California),
Gee-Way Lin1
Estimated H-index: 1
(SC: University of Southern California)
+ 6 AuthorsCheng-Ming Chuong61
Estimated H-index: 61
1 Citations Source Cite
Published on Dec 1, 2018in Nature Communications 12.35
Dongyang Cheng1
Estimated H-index: 1
(FZU: Fuzhou University),
Xiaoli Yan1
Estimated H-index: 1
(FZU: Fuzhou University)
+ 11 AuthorsWanzhong He1
Estimated H-index: 1
Branching morphogenesis is a general mechanism that increases the surface area of an organ. In chicken feathers, the flat epithelial sheath at the base of the follicle is transformed into periodic branches. How exactly the keratinocytes are organized into this pattern remains unclear. Here we show that in the feather follicle, the pre-branch basal keratinocytes have extensive filopodia, which contract and smooth out after branching. Manipulating the filopodia via small GTPases RhoA/Cdc42 also re...
5 Citations Source Cite
Published on Dec 1, 2018in BMC Genomics 3.73
Yung-Chih Lai4
Estimated H-index: 4
(SC: University of Southern California),
Ya-Chen Liang1
Estimated H-index: 1
(SC: University of Southern California)
+ 3 AuthorsCheng-Ming Chuong61
Estimated H-index: 61
Background The molecular mechanism controlling regional specific skin appendage phenotypes is a fundamental question that remains unresolved. We recently identified feather and scale primordium associated genes and with functional studies, proposed five major modules are involved in scale-to-feather conversion and their integration is essential to form today’s feathers. Yet, how the molecular networks are wired and integrated at the genomic level is still unknown.
1 Citations Source Cite