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Proteomic Contributions to Personalized Cancer Care

Published on Oct 1, 2008in Molecular & Cellular Proteomics4.83
· DOI :10.1074/mcp.R800002-MCP200
John M. Koomen38
Estimated H-index: 38
(USF: University of South Florida),
Eric B. Haura48
Estimated H-index: 48
(USF: University of South Florida)
+ 11 AuthorsWilliam S. Dalton77
Estimated H-index: 77
(USF: University of South Florida)
Abstract
Cancer impacts each patient and family differently. Our current understanding of the disease is primarily limited to clinical hallmarks of cancer, but many specific molecular mechanisms remain elusive. Genetic markers can be used to determine predisposition to tumor development, but molecularly targeted treatment strategies that improve patient prognosis are not widely available for most cancers. Individualized care plans, also described as personalized medicine, still must be developed by understanding and implementing basic science research into clinical treatment. Proteomics holds great promise in contributing to the prevention and cure of cancer because it provides unique tools for discovery of biomarkers and therapeutic targets. As such, proteomics can help translate basic science discoveries into the clinical practice of personalized medicine. Here we describe how biological mass spectrometry and proteome analysis interact with other major patient care and research initiatives and present vignettes illustrating efforts in discovery of diagnostic biomarkers for ovarian cancer, development of treatment strategies in lung cancer, and monitoring prognosis and relapse in multiple myeloma patients.
  • References (86)
  • Citations (77)
References86
Newest
#1Josep Villanueva (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 19
#2Arpi Nazarian (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 10
Last.Paul Tempst (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 125
view all 6 authors...
#1Peter O. Krutzik (Stanford University)H-Index: 20
#2Janelle M. Crane (Stanford University)H-Index: 2
Last.Garry P. Nolan (Stanford University)H-Index: 84
view all 4 authors...
#1Mazen W. Karaman (Ambit Biosciences)H-Index: 2
#2Sanna Herrgard (Ambit Biosciences)H-Index: 5
Last.Philip T. Edeen (Ambit Biosciences)H-Index: 3
view all 21 authors...
#1Uwe Rix (Anhui Medical University)H-Index: 28
#2Oliver Hantschel (Anhui Medical University)H-Index: 28
Last.Jacques Colinge (Austrian Academy of Sciences)H-Index: 36
view all 12 authors...
#1Klarisa Rikova (Cell Signaling Technology)H-Index: 7
#2Ailan Guo (Cell Signaling Technology)H-Index: 22
Last.Yu Li (Cell Signaling Technology)H-Index: 12
view all 30 authors...
#1Vitor Marcel Faça (Fred Hutchinson Cancer Research Center)H-Index: 26
#2Sharon J. Pitteri (Fred Hutchinson Cancer Research Center)H-Index: 31
Last.Jimmy K. Eng (Fred Hutchinson Cancer Research Center)H-Index: 68
view all 13 authors...
Cited By77
Newest
#1Peter Selby (University of Leeds)H-Index: 78
#2Rosamonde E. Banks (University of Leeds)H-Index: 50
Last.C McCabe (University of Alberta Hospital)
view all 53 authors...
#1Yanfeng Liu (Xi'an Jiaotong University)H-Index: 1
#2Lina Bu (Xi'an Jiaotong University)H-Index: 3
Last.Shuanying Yang (Xi'an Jiaotong University)H-Index: 5
view all 9 authors...
#1Tao Feng (NTU: Nanyang Technological University)
#2Yanli Zhao (NTU: Nanyang Technological University)
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