Determination of the dosage of clomipramine for the treatment of urine spraying in cats

Objective —To determine the optimal dosage of clomipramine for the treatment of urine spraying in cats. Design —Randomized controlled multicenter clinical trial. Animals —67 neutered cats. Procedure —Cats with a minimum 1-month history of spraying urine against vertical surfaces at least twice per week were randomly assigned to be treated with a placebo or with clomipramine at a dosage of 0.125 to 0.25 mg/kg (0.057 to 0.11 mg/lb), 0.25 to 0.5...