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Relaxant activity of raspberry (Rubus idaeus) leaf extract in guinea-pig ileum in vitro.

Published on Nov 1, 2002in Phytotherapy Research3.766
· DOI :10.1002/ptr.1040
Janne Rojas-Vera1
Estimated H-index: 1
(University of Portsmouth),
Asmita V. Patel15
Estimated H-index: 15
(University of Portsmouth),
C. G. Dacke5
Estimated H-index: 5
(University of Portsmouth)
Sources
Abstract
Tea made from the leaves of Rubus idaeus L. (raspberry) has been used for centuries as a folk medicine to treat wounds, diarrhoea, colic pain and as a uterine relaxant. Extracts of dried raspberry leaves prepared with different solvents, (n-hexane, ethyl acetate, chloroform and methanol) were tested in vitro for relaxant activity on transmurally stimulated guinea-pig ileum. The methanol (MeOH) extract exhibited the largest response and also indicated that the active compounds are of a relatively polar nature. Hence the bulk of the leaves were extracted with methanol and the dried extract fractionated on a silica gel column, eluting with chloroform, mixtures of chloroform and methanol and finally methanol. Each fraction was examined by thin layer chromatography and tested for relaxant activity in an in vitro transmurally stimulated guinea-pig ileum preparation. The fractions eluted with chloroform (CHCl3) lacked relaxant activity. Samples eluted with CHCl3/MeOH (95:5) had moderate relaxant activity, while a second distinctive peak of activity eluted with a more polar solvent mixture (CHCl3/MeOH 50:50) provided strong dose dependent responses. Evidence was obtained that there are at least two components of raspberry leaf extract which exhibit relaxant activity in an in vitro gastrointestinal preparation. Copyright © 2002 John Wiley & Sons, Ltd.
  • References (13)
  • Citations (32)
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#2G. W. Robertson (SCRI: Scottish Crop Research Institute)H-Index: 14
Last. A.N.E. Birch (SCRI: Scottish Crop Research Institute)H-Index: 14
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Abstract Epicuticular waxes from two cultivars of red raspberry ( Rubus idaeus ) were collected from the newly emerging crown leaves, and also from the group of four more mature leaves immediately below the crown. One cultivar, Autumn Bliss, was identified as aphid-resistant, and the other, Malling Jewel, as aphid-susceptible following bioassay with the large raspberry aphid, Amphorophora idaei , just prior to collection of the wax. Biological activity was primarily associated with the more matu...
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#1Rivaldo NieroH-Index: 20
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This work describes the antinociceptive effect of a triterpene glycoside, niga-ichigoside F1 (1), obtained from an EtOAc extract of the aerial parts of Rubus imperialis. When evaluated against an HOAc-induced writhing model, it exhibited an ID50 value of 3.1 mg/kg (ip). Moreover, in a formalin-induced pain model, both phases of pain were inhibited by compound 1, with ID50 values of 2.6 (first phase) and 2.7 (second phase) mg/kg, (ip), respectively.
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Currently, the incidence of lifestyle diseases is increasing due to inappropriate nutrition and environmental pollution. To prevent these diseases, various groups of bioactive compounds are needed with a broad spectrum of action and without adverse side effects. Polyphenolic compounds are the most widely studied group of this type of compounds. They occur widely in plants, but their content depends on many factors, including the type of plant, climatic conditions, and the date of harvest. The sp...
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Plants produce a number of compounds that are vital to the growth and development processes (primary metabolites) of cells and plant health. In addition to this type of metabolism, plants perform various processes that lead to taxonomically specific formation of compounds (secondary metabolites) that are a vital part of the human diet. Historically, plants have been used for their multiple benefits for the prevention and treatment of diseases. Rubus species are cultivated on all continents, at v...
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#1Paola FortiniH-Index: 11
#2P Di MarzioH-Index: 6
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Abstract Ethnopharmacological relevance New documentation of the uses of plants in the popular medicine of the Mainarde Mountain, a protected area of the central-southern Apennine characterised by a high floristic richness, is here reported. Materials and methods Field data were collected through semi-structured and open interviews with native People between 2011 and 2014. The plants were identified and vouchers specimens were scanned to create a Virtual Herbarium. The Ethnobotanicity Index (EI)...
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Aims: To investigate the hepatoprotective effects of red raspberry (Rubus idaeus L.) leaves against oxidative stress, inflammation and apoptosis induced by carbon tetrachloride (CCl4) in rats. Study Design and Methodology: Forty rats were divided into 5 groups, 1) normal control; 2) Raspberry (Rsp) control (100 mg/kg); 3) CCl4 control; 4) and 5) CCl4 groups pre-treated with 50 and 100 mg/kg of Rsp leaves, respectively, once daily for 10 days. Liver injury was induced on the 11th day in groups 3,...
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Aims: To investigate the hepatoprotective effects of red raspberry ( Rubus idaeus L. ) leaves against oxidative stress, inflammation and apoptosis induced by carbon tetrachloride (CCl 4) in rats. Study Design and Methodology: Forty rats were divided into 5 groups, 1) normal control; 2) Raspberry (Rsp) control (100 mg/kg); 3) CCl 4 control; 4) and 5) CCl 4 groups pre-treated with 50 and 100 mg/kg of Rsp leaves, respectively, once daily for 10 days. Liver injury was induced on the 11th day in grou...