Enhanced Tumor Formation in Mice Heterozygous for Blm Mutation
Abstract
Persons with the autosomal recessive disorder Bloom syndrome are predisposed to cancers of many types due to loss-of-function mutations in the BLM gene, which encodes a recQ-like helicase. Here we show that mice heterozygous for a targeted null mutation of Blm, the murine homolog of BLM, develop lymphoma earlier than wild-type littermates in response to challenge with murine leukemia virus and develop twice the number of intestinal tumors when...
Paper Details
Title
Enhanced Tumor Formation in Mice Heterozygous for Blm Mutation
Published Date
Sep 20, 2002
Journal
Volume
297
Issue
5589
Pages
2051 - 2053
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