Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells
Abstract
Variation on chromosome 9p21 is associated with risk of coronary artery disease (CAD). This genomic region contains the CDKN2A and CDKN2B genes which encode the cell cycle regulators p16(INK4a), p14(ARF) and p15(INK4b) and the ANRIL gene which encodes a non-coding RNA. Vascular smooth muscle cell (VSMC) proliferation plays an important role in the pathogenesis of atherosclerosis which causes CAD. We ascertained whether 9p21 genotype had an...
Paper Details
Title
Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells
Published Date
Sep 15, 2012
Journal
Volume
21
Issue
18
Pages
4021 - 4029
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