DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID
Abstract
Changes in DNA methylation are required for the formation of germinal centers (GCs), but the mechanisms of such changes are poorly understood. Activation-induced cytidine deaminase (AID) has been recently implicated in DNA demethylation through its deaminase activity coupled with DNA repair. We investigated the epigenetic function of AID in vivo in germinal center B cells (GCBs) isolated from wild-type (WT) and AID-deficient (Aicda−/−) mice. We...
Paper Details
Title
DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID
Published Date
Sep 1, 2015
Journal
Volume
12
Issue
12
Pages
2086 - 2098
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