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Long-term maintenance of weight loss after lifestyle intervention in frail, obese older adults

Published on Dec 6, 2012in Journal of Nutrition Health & Aging2.66
· DOI :10.1007/s12603-012-0421-5
Debra L. Waters26
Estimated H-index: 26
(University of Otago),
R. Vawter1
Estimated H-index: 1
+ 3 AuthorsDennis T. Villareal46
Estimated H-index: 46
Abstract
Objectives To determine if long-term weight loss with associated improvement in physical and metabolic health can be maintained after lifestyle intervention in frail, obese older adults.
  • References (26)
  • Citations (24)
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References26
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#1W. Jack Rejeski (Wake Forest University)H-Index: 58
#2Edward H. IpH-Index: 27
Last. Qiang ZhangH-Index: 9
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A b s t r ac t Background Adults with type 2 diabetes mellitus often have limitations in mobility that increase with age. An intensive lifestyle intervention that produces weight loss and improves fitness could slow the loss of mobility in such patients. Methods We randomly assigned 5145 overweight or obese adults between the ages of 45 and 74 years with type 2 diabetes to either an intensive lifestyle intervention or a diabetes support-and-education program; 5016 participants contributed data. ...
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#1Vanessa A. MilsomH-Index: 10
Last. Michael G. Perri (UF: University of Florida)H-Index: 52
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Few investigations of successful long-term weight loss beyond two years have been conducted, and none has examined weight changes in medically underserved rural populations of older adults. The purpose of this study was to assess long-term weight loss maintenance 3.5 years after the completion of an initial six-month lifestyle intervention for obesity among women aged 50-75 years residing in rural communities.One hundred and ten obese women with a mean (± standard deviation) age of 60.08 ± 6.17 ...
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#1Thomas A. Wadden (UPenn: University of Pennsylvania)H-Index: 104
#2Rebecca H. Neiberg (Wake Forest University)H-Index: 22
Last. Mara Z. Vitolins (Wake Forest University)H-Index: 48
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This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but...
260 CitationsSource
#1Stephen D. Anton (UF: University of Florida)H-Index: 36
#2Todd M. Manini (UF: University of Florida)H-Index: 46
Last. Michael G. Perri (UF: University of Florida)H-Index: 52
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Background: Obesity and a sedentary lifestyle are associated with physical impairments and biologic changes in older adults. Weight loss combined with exercise may reduce inflammation and improve physical functioning in overweight, sedentary, older adults. This study tested whether a weight loss program combined with moderate exercise could improve physical function in obese, older adult women.
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#1W. Jack RejeskiH-Index: 58
#2Shannon L. MihalkoH-Index: 25
Last. Jacquelyn W. McClelland (NCSU: North Carolina State University)H-Index: 13
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Objectives. Using the weight efficacy lifestyle questionnaire (WEL), we examined whether a group-mediated inter vention for weight loss among older, obese adults resulted in changes in self-regulatory self-efficacy for eating behavior and whether these changes mediated weight loss. Methods. This was a randomized controlled design, and 288 older adults received 1 of 3 treatments for 6 months: physical activity only (PA), weight loss + physical activity (WL + PA), or a successful aging (SA) health...
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#1Dennis T. Villareal (VA: United States Department of Veterans Affairs)H-Index: 46
#2Suresh ChodeH-Index: 4
Last. Krupa ShahH-Index: 17
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#1Thang S. Han (AU: Ashford University)H-Index: 48
#2Abdelouahid Tajar (MAHSC: Manchester Academic Health Science Centre)H-Index: 28
Last. Michael E. J. LeanH-Index: 79
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Our population is ageing, and obesity is increasing in the elderly bringing massive and rapidly changing burdens of ill health related to increased body weights and fat as well as the main drivers of poor diet and inactivity. Overweight and obesity, and a static body mass index (BMI) commonly conceal sarcopenia (gain in body fat but loss of muscle mass and functional capacity) in older people, aggravated by inactivity. A systematic computerized literature search using an iterative manipulation p...
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#1Eileen M. Weinheimer (Purdue University)H-Index: 5
#2Laura P. Sands (Purdue University)H-Index: 46
Last. Wayne W. Campbell (Purdue University)H-Index: 50
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The systematic review presented here assessed the effects of energy restriction (ER) and exercise (EX) on fat-free mass (FFM) in overweight and obese middle-aged and older adults. PubMed was searched using the key words “weight loss or energy restriction” AND “skeletal muscle or body composition,” with limitations set for “human” and “middle-aged and aged.” Results from 52 studies are reported as the percentages of EX (mainly aerobic training), ER, or ER+EX groups that had a specified change in ...
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Purpose of reviewThe role of calorie restriction in humans is controversial. Recently, new data in monkeys and humans have provided new insights into the potential role of calorie restriction in longevity.Recent findingsA study in rhesus monkeys showed a reduction in aging-associated mortality. A nu
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#1Krupa Shah (WashU: Washington University in St. Louis)H-Index: 17
#2Abby Stufflebam (WashU: Washington University in St. Louis)H-Index: 1
Last. Dennis T. Villareal (WashU: Washington University in St. Louis)H-Index: 46
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Both obesity and aging increase intrahepatic fat (IHF) content, which leads to nonalcoholic fatty liver disease (NAFLD) and metabolic abnormalities such as insulin resistance. We evaluated the effects of diet and diet in conjunction with exercise on IHF content and associated metabolic abnormalities in obese older adults. Eighteen obese (BMI ≥30 kg/m 2 ) older (≥65 years old) adults completed a 6-month clinical trial. Participants were randomized to diet (D group; n = 9) or diet + exercise (D+E ...
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#1Reina Armamento-Villareal (BCM: Baylor College of Medicine)H-Index: 24
#2Lina E. Aguirre (UNM: University of New Mexico)H-Index: 7
Last. Dennis T. Villareal (BCM: Baylor College of Medicine)H-Index: 46
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Weight loss therapy of older adults with obesity is limited by weight loss-induced decrease in bone mineral density (BMD), which could exacerbate ongoing age-related bone loss and increase the risk for fractures. Therefore, it is recommended that weight loss therapy of older adults with obesity should include an intervention such as regular exercise to reduce the concomitant bone loss. However, the most appropriate exercise types to combine with weight loss therapy in this older population is un...
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#1Daniel E. Kammire (Wake Forest University)
#2Michael P. Walkup (Wake Forest University)H-Index: 21
Last. Kristen M. Beavers (Wake Forest University)H-Index: 16
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OBJECTIVE: This study aimed to examine change in bone mineral density (BMD) and trabecular bone score among older adult weight regainers (WR) and weight maintainers (WM). METHODS: Observational data come from 77 older adults (mean age: 67 [SD 5] years; 69% women; 70% white) with obesity (mean BMI: 33.6 [SD 3.7] kg/m2 ) who lost weight during an 18-month weight loss intervention. Total body mass and body composition, along with regional (total hip, femoral neck, lumbar spine) BMD and trabecular b...
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#1Jake Turicchi (University of Leeds)H-Index: 1
#2Ruairi O'Driscoll (University of Leeds)H-Index: 1
Last. R. James Stubbs (University of Leeds)H-Index: 30
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: Weight regain following weight loss is common although little is known regarding the associations between amount, rate, and composition of weight loss and weight regain. Forty-three studies (52 groups; n = 2379) with longitudinal body composition measurements were identified in which weight loss (≥5%) and subsequent weight regain (≥2%) occurred. Data were synthesized for changes in weight and body composition. Meta-regression models were used to investigate associations between amount, rate, a...
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#1Cilla Haywood (University of Melbourne)H-Index: 5
#2Priya Sumithran (University of Melbourne)H-Index: 8
The study aims to systematically review the available evidence regarding weight loss interventions (lifestyle, surgical, and pharmacological) for obesity in adults aged over 60 years. A search of prospective, randomized studies took place in January 2018, on Medline (Web of Science) and PubMed databases. Search terms included the following: elderly, obese, hypocaloric, pharmacotherapy, and bariatric surgery. Abstracts were screened for eligibility. A total of 256 publications regarding lifestyle...
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#2Carliene van Dronkelaar (Hogeschool van Amsterdam)H-Index: 1
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Increased physical activity and dietary protein intake are promising interventions to prevent or treat the age-related decline in physical performance in older adults. There are well-controlled exercise as well as dietary intervention studies that show beneficial effects on physical performance in older adults. In practice, however, weekly group based exercise or nutritional programs may not be as effective. To optimise these exercise programs for community dwelling older adults, a digitally sup...
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#1John A. Batsis (The Dartmouth Institute for Health Policy and Clinical Practice)H-Index: 27
#2Dennis T. Villareal (BCM: Baylor College of Medicine)H-Index: 46
The prevalence of obesity in combination with sarcopenia (the age-related loss of muscle mass and strength or physical function) is increasing in adults aged 65 years and older. A major subset of adults over the age of 65 is now classified as having sarcopenic obesity, a high-risk geriatric syndrome predominantly observed in an ageing population that is at risk of synergistic complications from both sarcopenia and obesity. This Review discusses pathways and mechanisms leading to muscle impairmen...
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#1Sepideh Soltani (IUMS: Iran University of Medical Sciences)H-Index: 4
#2Gary R. Hunter (UAB: University of Alabama at Birmingham)H-Index: 61
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Summary We assessed the impact of weight loss strategies including calorie restriction and exercise training on BMD in adults using a systematic review of randomized controlled trials. Weight reduction results in reduced BMD at the hip, but has less effect on the spine. Both calorie restriction and a combination of calorie restriction and exercise result in a decrease in hip bone density, whereas weight loss response to exercise training without dietary restriction leads to increased hip BMD.
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