pH-Controllable drug release using hydrogel encapsulated mesoporous silica
Abstract
Amine-functionalized mesoporous SBA-15 silica loaded with bovine serum albumin (BSA) has been successfully encapsulated with a thin layer coating of poly(acrylic acid) PAA, with the entrapped BSA being released from the PAA-encapsulated SBA-15 at the higher pH value of 7.4 rather than at the lower pH value of 1.2. This novel drug delivery system has a potential application in the release of protein drug to the site of higher pH value, such as...
Paper Details
Title
pH-Controllable drug release using hydrogel encapsulated mesoporous silica
Published Date
Jan 1, 2007
Journal
Issue
42
Pages
4396 - 4396
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