The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis

Objective. null —This article defines stress and related concepts and reviews their historical development. The notion of a stress system as the effector of the stress syndrome is suggested, and its physiologic and pathophysiologic manifestations are described. A new perspective on human disease states associated with dysregulation of the stress system is provided. null Data Sources. null —Published original articles from human and animal...