Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis

Volume: 57, Issue: 1, Pages: 12 - 25
Published: Feb 1, 2010
Abstract
The renin-angiotensin system (RAS) has been demonstrated to play a critical role in the initiation and progression of atherosclerosis, thereby contributing to development of cardiovascular diseases. Angiotensin II (Ang II), a major substrate in RAS, stimulates atherosclerosis through various deleterious effects such as endothelial dysfunction, cellular proliferation and inflammation. Recently, local RAS in vasculature is reported to play an...
Paper Details
Title
Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis
Published Date
Feb 1, 2010
Volume
57
Issue
1
Pages
12 - 25
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