Reining in H2O2 for Safe Signaling

Mammalian cells use hydrogen peroxide (H2O2) not only to kill invading pathogens, but also as a signaling modulator. Woo et al., 2010Woo H.A. Yim S.H. Shin D.H. Kang D. Yu D.-Y. Rhee S.G. Cell. 2010; (this issue)Google Scholar now show that the local inactivation of a H2O2-degrading enzyme ensures that the production of this oxidant is restricted to the signaling site. Mammalian cells use hydrogen peroxide (H2O2) not only to kill invading...