SIRT2 directs the replication stress response through CDK9 deacetylation

Volume: 110, Issue: 33, Pages: 13546 - 13551
Published: Aug 13, 2013
Abstract
Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor. We show that SIRT2 directs replication stress responses by regulating the activity of cyclin-dependent kinase 9 (CDK9), a protein required for recovery from replication arrest. SIRT2 deficiency results in replication stress sensitivity, impairment in recovery from replication arrest, spontaneous...
Paper Details
Title
SIRT2 directs the replication stress response through CDK9 deacetylation
Published Date
Aug 13, 2013
Volume
110
Issue
33
Pages
13546 - 13551
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