Classes of fast and specific search mechanisms for proteins on DNA
Abstract
Problems of search and recognition appear over different scales in biological systems. In this review we focus on the challenges posed by interactions between proteins, in particular transcription factors, and DNA and possible mechanisms which allow for a fast and selective target location. Initially we argue that DNA-binding proteins can be classified, broadly, into three distinct classes which we illustrate using experimental data. Each class...
Paper Details
Title
Classes of fast and specific search mechanisms for proteins on DNA
Published Date
Apr 5, 2011
Journal
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