Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web‐based target finding tool
Volume: 111, Issue: 8, Pages: 1604 - 1616
Published: May 22, 2014
Abstract
Chinese hamster ovary (CHO) cells are widely used in the biopharmaceutical industry as a host for the production of complex pharmaceutical proteins. Thus genome engineering of CHO cells for improved product quality and yield is of great interest. Here, we demonstrate for the first time the efficacy of the CRISPR Cas9 technology in CHO cells by generating site‐specific gene disruptions in COSMC and FUT8, both of which encode proteins involved in...
Paper Details
Title
Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web‐based target finding tool
Published Date
May 22, 2014
Volume
111
Issue
8
Pages
1604 - 1616
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